Pharmacokinetics: Invasion half-life of clenbuterol is 1 hr; the distribution corresponds to an open 2-compartment model with a side-compartment. Elimination from plasma takes place in 2 phases, the half-life of the α-phase being 1 hr and that of the α-phase 34 hrs. Elimination is primarily renal (87% after 168 hrs). Dose intervals of 12 hrs suffice to maintain a plasma level. 5 metabolites have been found in humans.
INDICATIONS: Prophylaxis and therapy of bronchospasm in bronchial asthma, chronic bronchitis and bronchitis associated with emphysema.
DOSAGE & ADMINISTRATION: The recommended total daily dose for adults and children >12 years is 0.04 mg/day In severe bronchospasm the dose may be increased to 0.08 mg/day twice daily; as therapy continues, the dose may often be reduced to 0.02 mg/day.
Tablet: Adults and Children > 12 years: 0.02 mg twice daily. Children < 12 years: According to body weight.